期刊
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
卷 374, 期 1, 页码 66-72出版社
ACADEMIC PRESS INC
DOI: 10.1006/abbi.1999.1607
关键词
syndecan; fibronectin; adhesion; proteoglycans; signaling
资金
- NIDDK NIH HHS [DK54605] Funding Source: Medline
- NIGMS NIH HHS [GM 50194] Funding Source: Medline
Cell adhesion to extracellular matrix involves signaling mechanisms which control attachment, spreading and the formation of focal adhesions and stress fibers. Fibronectin can provide sufficient signals for all three processes, even when protein synthesis is prevented by cycloheximide. Primary fibroblasts attach and spread following integrin ligation, but do not form focal adhesions unless treated with a heparin-binding fragment of fibronectin (HepII), a peptide from this domain, or phorbol esters to activate protein kinase C. Syndecan-4 heparan sulfate proteoglycan is a transmembrane component present together with integrins in focal adhesions, Syndecan-4 binds and activates protein kinase C alpha, whose activity is needed for focal adhesion formation. We now report that the glycosaminoglycan chains of syndecan-4 bind recombinant HepII and it is incorporated into forming focal adhesions. (C) 2000 Academic Press.
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