期刊
BRITISH JOURNAL OF CANCER
卷 82, 期 3, 页码 514-517出版社
NATURE PUBLISHING GROUP
DOI: 10.1054/bjoc.1999.0955
关键词
DNA hypermethylation; ribosomal DNA; breast cancer
类别
资金
- NCI NIH HHS [CA-69065] Funding Source: Medline
We examined the methylation status of the transcribed domain of ribosomal DNA (rDNA) in 58 patients with breast cancer. The mean percent of methylation was significantly higher in breast tumours than that of normal control samples (P < 0.0001). This increased rDNA methylation was associated with oestrogen receptor non-expression (P < 0.0273) and with moderately or poorly differentiated tumours as compared to well differentiated tumours (P < 0.0475). Our results suggest that rDNA can be a useful marker for monitoring aberrant methylation during breast tumour progression. (C) 2000 Cancer Research Campaign.
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