期刊
JOURNAL OF CELL BIOLOGY
卷 209, 期 4, 页码 493-506出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201412147
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资金
- Swiss National Science Foundation
- Swiss Multiple Sclerosis Society
- European Union's Seventh Framework Program (FP7) [241861, 607962]
- German Research Foundation
Unique intercellular junctional complexes between the central nervous system (CNS) microvascular endothelial cells and the choroid plexus epithelial cells form the endothelial blood brain barrier (BBB) and the epithelial blood cerebrospinal fluid barrier (BCSFB), respectively. These barriers inhibit paracellular diffusion, thereby protecting the CNS from fluctuations in the blood. Studies of brain barrier integrity during development, normal physiology, and disease have focused on BBB and BCSFB tight junctions but not the corresponding endothelial and epithelial adherens junctions. The crosstalk between adherens junctions and tight junctions in maintaining barrier integrity is an understudied area that may represent a promising target for influencing brain barrier function.
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