期刊
BIOMEDICAL MICRODEVICES
卷 15, 期 1, 页码 17-25出版社
SPRINGER
DOI: 10.1007/s10544-012-9683-2
关键词
Hollow microneedles; Bevel angle; Minimal invasion; Blood extraction
资金
- Public Welfare & Safety Research Program through the National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [2010-0020772]
- Korean Health Technology R&D Project, Ministry for Health, Welfare, Republic of Korea [A102003]
- Korea Health Promotion Institute [A102003, HI10C1959010013] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2010-0020774] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The healthcare system relies widely on biochemical information obtained from blood sample extracted via hypodermic needles, despite the invasiveness and pain associated with this procedure. Therefore, an alternative micro-scale needle for minimally invasive blood sampling is highly desirable. Traditional fabrication techniques to create microneedles do not generate needles with the combined features of a sharp tip, long length, and hollow structure concurrently. Here, we report the fabrication of a microneedle long enough to reach blood vessels and sharp enough to minimize nerve contact for minimally invasive blood extraction. The microneedle structure was precisely controlled using a drawing lithography technique, and a sharp tip angle was introduced using a laser-cutting system. We investigated the characteristics of a microneedle with a length of 1,800 mu m length, an inner diameter of 60 mu m, a tip diameter of 120 mu m, and a 15A degrees bevel angle through in-vitro liquid extraction and mechanical strength analysis. We demonstrated that the proposed structure results in blood extraction at a reasonable rate, and that a microneedle with this geometry can reliably penetrate skin without breaking. We integrated this microneedle into a blood extraction device to extract a 20 mu l volume of mouse blood in-vivo. Our optimized, hollow microneedle can potentially be incorporated with other cutting-edge technologies such as microactuators, biosensors, and microfluidic chips to create blood analysis systems for point-of-care diagnostics.
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