期刊
BIOMEDICAL MICRODEVICES
卷 11, 期 4, 页码 763-772出版社
SPRINGER
DOI: 10.1007/s10544-009-9291-y
关键词
Holmium; Microspheres; Neutron irradiation; PLLA; Liver; Tumor
资金
- Dutch Technology Foundation STW [6069]
Poly(L-lactic acid) microspheres loaded with holmium-166 acetylacetonate (Ho-166-PLLA-MS) are a novel microdevice for intra-arterial radioembolization in patients with unresectable liver malignancies. The neutron activation in a nuclear reactor, in particular the gamma heating, damages the Ho-166-PLLA-MS. The degree of damage is dependent on the irradiation characteristics and irradiation time in a particular reactor facility. The aim of this study was to standardize and objectively validate the activation procedure in a particular reactor. The methods included light- and scanning electron microscopy (SEM), particle size analysis, differential scanning calorimetry, viscometry, thermal neutron flux measurements and energy deposition calculations. Seven hours-neutron irradiation results in sufficient specific activity of the Ho-166-PLLA-MS while structural integrity is preserved. Neutron flux measurements and energy deposition calculations are required in the screening of other nuclear reactors. For the evaluation of microsphere quality, light microscopy, SEM and particle size analysis are appropriate techniques.
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