期刊
JOURNAL OF CHROMATOGRAPHY A
卷 869, 期 1-2, 页码 129-135出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0021-9673(99)00864-X
关键词
gamma radiation; stationary phases, LC; column stability; poly(methyloctylsiloxane); zirconized silica
Reversed-phase packing materials were prepared from HPLC silica and from zirconized HPLC silica support particles having sorbed poly(methyloctylsiloxane) (PMOS) as the stationary phase. Portions of zirconized material were subjected to 80 kGy of ionizing radiation. Columns prepared from these packing materials were subjected to 5000 column volumes each of neutral and alkaline (pH 10) mobile phases, with periodic tests to evaluate chromatographic performance. It was shown that the PMOS stationary phase sorbed onto zirconized silica requires an immobilization treatment (such as gamma irradiation) for long term stability while prior surface zirconization of the silica support surface greatly improves the chromatographic stability of the stationary phase when using alkaline mobile phases. (C) 2000 Elsevier Science B.V. All rights reserved.
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