期刊
BIOMEDICAL MICRODEVICES
卷 12, 期 1, 页码 169-177出版社
SPRINGER
DOI: 10.1007/s10544-009-9373-x
关键词
Biomaterial; Functional; Monodisperse; Microfluidic device; Microspheres; Large-sized
资金
- Shanghai Municipal Education Commission [07SG37]
- Natural Science Foundation of China [50772022, 50772127]
- Shanghai Leading Academic Discipline Project [B603]
- Cultivation Fund of the Key Scientific and Technical Innovation Project [708039]
- Program of Introducing Talents of Discipline to Universities [111-2-04]
We report a novel and facile method for fabricating coaxial microfluidic devices processing various dimensions at low cost, in which polypropylene hollow fibers or glass capillaries are used as the tip of the dispersed phase injection tube. With this coaxial microfluidic device, monodisperse biocompatible microspheres ranging from 300 to 800 mu m were obtained by collecting oil-in-water or water-in-oil emulsions and solidifying the suspended microspheres. Microsphere size could be controlled by changing the tips or tuning the concentrations of the dispersed and continuous phases. By adding functional nanoparticles into the dispersed phase, it was demonstrated that fluorescent and magnetic microspheres can be fabricated easily using these microfluidic devices.
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