期刊
BIOMEDICAL MICRODEVICES
卷 11, 期 1, 页码 129-133出版社
SPRINGER
DOI: 10.1007/s10544-008-9216-1
关键词
Ice lithography; Concave microwell; PDMS; 3D microstructure; Water mold
资金
- Korea government (MOST) [R0A-2007-000-20086-0]
- Korea Health 21 RD Project
- Ministry of Health & Welfare, Republic of Korea [0405-ER01-0304-0001]
- National Research Foundation of Korea [2007-0056875] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
We describe a novel method to produce concave microwells utilizing solid-liquid phase change. This method, named 'ice-lithography', does not require any lithographic processes and consists of a few simple steps that yield multiple concave microwells. We demonstrated that the shape and size of the microwells can be controlled by varying substrates and vapor-collection time. Patterned wells with sizes in the range of 10 mu m to several millimeters in diameter could be produced. Additionally, we fabricated a uniformly aligned concave microwell pattern and a microfluidic network. Ice-lithography has potential biological and biomedical applications in areas such as the fabrication of cell docking devices and microbioreactors as well as the formation of uniformly sized embryoid bodies.
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