期刊
BIOMEDICAL MATERIALS
卷 9, 期 3, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/1748-6041/9/3/035005
关键词
bacterial cellulose; silver nanoparticles; antimicrobial activities; biocompatibility; second-degree wound
资金
- National Natural Science Foundation of China Project [51073024, 51273021]
- National Science and Technology Support Project of China [2011BAK15B04]
Bacterial cellulose (BC) has attracted increasing attention as a novel wound dressing material, but its antimicrobial activity, which is one of the critical skin-barrier functions in wound healing, is not sufficient for use in practical applications. To overcome such a deficiency, silver nanoparticles were generated and self-assembled on the surface of BC nanofibers, forming a stable and evenly distributed Ag nanoparticle coated BC nanofiber (AgNP-BC). The performance of AgNP-BC was systematically studied in terms of antibacterial activities, cytocompatibility and effects on wound healing. The results showed that AgNP-BC exhibited significant antibacterial activity against Staphylococcus aureus. Moreover, AgNP-BC allowed attachment, and growth of rat fibroblasts with low cytotoxicity emerged. Based on these advantages, AgNP-BC samples were applied in a second-degree rat wound model. Wound flora showed a significant reduction during the healing. The fresh epidermal and dermis thicknesses with AgNP-BC samples were 111 and 855 mu m respectively, higher than 74 and 619 mu m for BC groups and 57 and 473 mu m for untreated control wounds. The results demonstrated that AgNP-BC could reduce inflammation and promote scald wound healing.
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