期刊
BIOMEDICAL MATERIALS
卷 7, 期 4, 页码 -出版社
IOP Publishing Ltd
DOI: 10.1088/1748-6041/7/4/045005
关键词
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资金
- Nano Mission Council [SR/S5/NM-07/2006, SR/NM/PG-16/2007]
- Department of Science and Technology, India
- FIST, Department of Science and Technology, India [SR/FST/LSI-327/2007]
- Drugs and Pharmaceuticals Research Programme [VII-PRDSF/100/0506/TDT]
- SASTRA University for the Central Animal Facility
Electrospinning is a versatile technique to make biomimetic and nanostructured scaffolds for skin tissue engineering. In this study we have electrospun and characterized chitosan (C)-poly(vinyl alcohol) (PVA) blend nanofibers as dermal substitutes and compared with 2D C-PVA films. The in vitro characterization of the C-PVA nanofibers and 2D films were evaluated using mouse 3T3 fibroblast cells and our results demonstrated that the cells adhered and proliferated on the surface of C-PVA nanofibers. In our animal studies, the implantation of C-PVA nanofibers along with topical administration of growth factor R-Spondin 1 on full thickness wounds created on rats showed 98.6% wound closure after two weeks post-surgery. The catalase and superoxide dismutase activity of the healing tissue was significantly higher in the groups treated with topical administration of growth factor and C-PVA nanofibers (p < 0.05). Thus these C-PVA nanofibers along with novel growth factor are promising new biomaterials that could be used as dermal substitutes for accelerated wound healing.
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