期刊
FEBS LETTERS
卷 468, 期 1, 页码 84-88出版社
WILEY
DOI: 10.1016/S0014-5793(00)01202-3
关键词
ARF-like protein; cell polarity; cofactor; GTP-binding protein; microtubule; fission yeast
The proper folding of tubulins and their incorporation into microtubules consist of a series of reactions. in which evolutionarily conserved proteins, cofactors A to E, play a vital role. We have cloned a fission east gene (alp41(+)) which encodes a highly conserved small GTP-binding protein homologous to budding yeast CIN4 and human ARF-like Arl2. alp41(+) is essential, disruption of which results in microtubule dysfunction and growth polarity defects. Genetic analysis indicates that Alp41 plays a crucial role in the cofactor-dependent pathway, in which it functions upstream of the cofactor D homologue Alp1(D) and possibly in concert with Alp21(E) (C) 2000 Federation of European Biochemical Societies.
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