期刊
ONCOGENE
卷 19, 期 8, 页码 1028-1037出版社
STOCKTON PRESS
DOI: 10.1038/sj.onc.1203281
关键词
DCIS; ductal carcinoma in situ; mouse model; SV40 large T-antigen
The ductal carcinoma in situ (DCIS) of the mammary gland represents an early, pre-invasive stage in the development of invasive breast carcinoma and is increasingly diagnosed since the introduction of high-quality mammography screening. Uncertainties in the prognosis for patients with DCIS have caused a controversial discussion about adequate treatment, and it is suspected that most patients undergoing mastectomy may be overtreated, In order to improve treatment and treatment decision, it therefore is highly desirable to identify prognostic markers and therapeutic targets for DCIS. We here introduce a set of transgenic mice (WAP-T and WAP-T-NP lines) presenting with various morphological forms of DCLS-like lesions. In these mite the SV40 large tumor antigen is specifically induced in epithelial cells of the terminal duct lobular units (TDLU), As a consequence of continuous expression of the oncogene, the animals develop multifocal DCIS and consequently invasive carcinoma within strain specific periods of latency. DCIS lesions in transgenic mire exhibit distinct architectural and cytological features which closely resemble those commonly present in humans, We therefore propose these transgenic lines as an experimental model to study the underlying molecular events leading to DCIS and its progression to invasive disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据