期刊
JOURNAL OF CELL BIOLOGY
卷 208, 期 3, 页码 313-329出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201403111
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资金
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- Israel Science Foundation
- European Community's Seventh Framework Program UE-FP7 (Neuron-Glia Interactions in Nerve Development and Disease)
- [R01 NS045630]
- [NS055256]
- [NS50220]
- [DK36425]
Fast neural conduction requires accumulation of Na+ channels at nodes of Ranvier. Dedicated adhesion molecules on myelinating cells and axons govern node organization. Among those, specific laminins and dystroglycan complexes contribute to Na+ channel clustering at peripheral nodes by unknown mechanisms. We show that in addition to facing the basal lamina, dystroglycan is found near the nodal matrix around axons, binds matrix components, and participates in initial events of nodogenesis. We identify the dystroglycan-ligand perlecan as a novel nodal component and show that dystroglycan is required for the selective accumulation of perlecan at nodes. Perlecan binds the clustering molecule gliomedin and enhances clustering of node of Ranvier components. These data show that proteoglycans have specific roles in peripheral nodes and indicate that peripheral and central axons use similar strategies but different molecules to form nodes of Ranvier. Further, our data indicate that dystroglycan binds free matrix that is not organized in a basal lamina.
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