期刊
SCIENCE
卷 287, 期 5457, 页码 1500-1503出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.287.5457.1500
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资金
- NEI NIH HHS [EY07566, EY11629] Funding Source: Medline
Latent infections with periodic reactivation are a common outcome after acute infection with many viruses, The Latency-associated transcript (LAT) gene is required for wild-type reactivation of herpes simplex virus (HSV), However, the underlying mechanisms remain unclear. In rabbit trigeminal ganglia, extensive apoptosis occurred with LAT(-) virus but not with LAT(+) viruses. In addition, a plasmid expressing LAT blocked apoptosis in cultured cells. Thus, LAT promotes neuronal survival after HSV-1 infection by reducing apoptosis.
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