期刊
VACCINE
卷 18, 期 16, 页码 1654-1660出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0264-410X(99)00502-2
关键词
protein kinase C; c-Jun N-terminal kinase; T-cell activation; signal transduction; immune senescence
资金
- NIA NIH HHS [AG09801, AG08808] Funding Source: Medline
Studies of the early stages of T-cell activation reveal that T cells from aged mice show multiple abnormalities within the first few minutes after stimulation, including decline in the activation of the Raf-1/MEK/ERK kinases and in JNK protein kinase. Zap-70 kinase associated with the CD3 zeta chain shows a 2-fold increase with age in resting CD4 T cells, despite a three-fold decline with age in the levels of tyrosine phosphorylation of CD3 zeta; nonetheless, there is no effect of aging on Zap-70 kinase function in activated T cells as measured by in vitro kinase methods. Age-related impairment of the translocation of PKC theta from cytoplasm to the site of T-cell interaction with antigen-presenting cells may underlie downstream defects in the activation cascade. (C) 2000 Elsevier Science Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据