期刊
JOURNAL OF INFECTIOUS DISEASES
卷 181, 期 3, 页码 1206-1209出版社
OXFORD UNIV PRESS INC
DOI: 10.1086/315353
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The multiplication rates and invasiveness of Plasmodium falciparum parasites isolated from adult Thai patients hospitalized with uncomplicated malaria (n = 34) were compared with those from persons with severe malaria (n = 42), To simulate severe malaria and control for host effects, the in vitro cultures were adjusted to 1% parasitemia and used the same red blood cell donor. P. falciparum isolates from persons with severe malaria had initial cycle multiplication rates in vitro that were 3-fold higher than those from uncomplicated malaria (median [95% confidence interval], 8.3 [7.1-10.5] vs. 2.8 [1.7-3.9]; P = .001), Parasites causing severe malaria exhibited unrestricted red blood cell invasion, whereas those from uncomplicated malaria were restricted to a geometric mean of 40 (31%-53%) of red blood cells. P. falciparum parasites causing severe malaria were less selective and multiplied more at high parasitemias than those causing uncomplicated malaria.
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