期刊
NATURE CELL BIOLOGY
卷 2, 期 3, 页码 173-177出版社
MACMILLAN MAGAZINES LTD
DOI: 10.1038/35004052
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资金
- NHLBI NIH HHS [HL62494, HL03727] Funding Source: Medline
A dynamic positive feedback mechanism, known as 'facilitation', augments L-type calcium-ion currents (I-Ca) in response to increased intracellular Ca2+ concentrations. The Ca2+-binding protein calmodulin (CaM) has been implicated in facilitation, but the single-channel signature and the signalling events underlying Ca2+/CaM-dependent facilitation are unknown. Here we show that the Ca2+/CaM-dependent protein kinase II (CaMK) is necessary and possibly sufficient for I-Ca facilitation. CaMK induces a channel-gating mode that is characterized by frequent, long openings of L-type Ca2+ channels. We conclude that CaMK-mediated phosphorylation is an essential signalling event in triggering Ca2+/CaM-dependent I-Ca facilitation.
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