期刊
BIOMEDICAL CHROMATOGRAPHY
卷 28, 期 5, 页码 637-647出版社
WILEY-BLACKWELL
DOI: 10.1002/bmc.3082
关键词
fatty liver; HPLC; hawthorn leaf extract (HLE); tissue distribution
类别
资金
- Shenyang Science and Technology Planning Project Foundation, China [F13-194-9-00]
Hawthorn leaves, a well-known traditional Chinese medicine, have been widely used for treating cardiovascular and fatty liver diseases. The present study aimed to investigate the therapeutic basis treating fatty liver disease by comparing the tissue distribution of six compounds of hawthorn leaf extract (HLE) in fatty liver rats and healthy rats after oral administration at first day, half month and one month, separately. Therefore, a sensitive and specific HPLC method with internal standard was developed and validated to determine chlorogenic acid, vitexin-4-O-glucoside, vitexin-2-O-rhamnoside, vitexin, rutin and hyperoside in the tissues including heart, liver, spleen, kidney, stomach and intestine. The results indicated that the six compounds in HLE presented some bioactivity in treating rat fatty liver as the concentrations of the six compounds varied significantly in inter- and intragroup comparisons (healthy and/or fatty liver group). Copyright (c) 2013 John Wiley & Sons, Ltd.
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