期刊
MECHANISMS OF DEVELOPMENT
卷 91, 期 1-2, 页码 143-152出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0925-4773(99)00287-7
关键词
primordial germ cells; cadherins; cell migration; gonadogenesis; flow cytometry; RT-PCR; immunohistochemistry; green fluorescent protein; transgenic mice
资金
- NICHD NIH HHS [HD00850-10, HD33440-01] Funding Source: Medline
Primordial germ cells (PGCs) are the founder cells of the gametes. In mammals, PGCs migrate from the hindgut to the genital ridges, where they coalesce with each other and with somatic cells to form the primary sex cords. We show here that, in both sexes, PGCs express P- and E-cadherins during and after migration, and N-cadherin at post-migratory stages. E-Cadherin is not expressed by PGCs whilst in the hindgut, but is upregulated as they leave. Blocking antibodies against E-, but not P-cadherin cause defective PGC-PGC coalescence, and in some cases, ectopic PGCs. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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