期刊
BIOMEDICAL CHROMATOGRAPHY
卷 25, 期 1-2, 页码 1-10出版社
WILEY
DOI: 10.1002/bmc.1548
关键词
derivatization; chromatography; electrospray; tandem mass spectrometry
类别
资金
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
Liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) is one of the most prominent analytical techniques owing to its inherent selectivity and sensitivity. In LC/ESI-MS/MS, chemical derivatization is often used to enhance the detection sensitivity. Derivatization improves the chromatographic separation, and enhances the mass spectrometric ionization efficiency and MS/MS detectability. In this review, an overview of the derivatization reagents which have been applied to LC/ESI-MS/MS is presented, focusing on the applications to low molecular weight compounds. Copyright (C) 2010 John Wiley & Sons, Ltd.
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