期刊
SCIENCE
卷 287, 期 5458, 页码 1660-1664出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.287.5458.1660
关键词
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资金
- NIMH NIH HHS [R01 MH063271, P50 MH44866, P50 MH068789, MH56608] Funding Source: Medline
The synergistic response of cells to the stimulation of multiple receptors has been ascribed to receptor cross talk: however, the specific molecules that mediate the resultant signal amplification have not been defined. Here a 24-kilodalton single transmembrane protein, designated calcyon, we functionally characterize that interacts with the D1 dopamine receptor. Calcyon Localizes to dendritic spines of D1 receptor-expressing pyramidal cells in prefrontal cortex. These studies delineate a mechanism of G(q)- and G(s)-coupled heterotrimeric CTP-binding protein-coupled receptor cross talk by which D1 receptors can shift effector coupling to stimulate robust intracellular calcium (Ca(i)(2+)) release as a result of interaction with calcyon. The role of calcyon in potentiating Ca(2+)-dependent signaling should provide insight into the D1 receptor-modulated cognitive functions of prefrontal cortex.
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