期刊
FEBS LETTERS
卷 469, 期 1, 页码 19-23出版社
WILEY
DOI: 10.1016/S0014-5793(00)01247-3
关键词
misshapen/NIKs-related kinase; signal transduction; germinal center kinase family kinase; mitogen-activated protein kinase; stress-activated protein kinase
A new germinal center kinase (GCK) family kinase, Misshapen/NIKs-related kinase (MINK), has been cloned and its expression has been characterized in several tissues and various developmental stages of the mouse brain. MINK encodes a 1300 amino acid polypeptide, consisting of an N-terminal kinase domain, a proline-rich intermediate region, and a C-terminal GCK homology region. The expression of MINK is up-regulated during the postnatal development of the mouse brain. MINK activates the cJun N-terminal kinase and the p38 pathways. (C) 2000 Federation of European Biochemical Societies.
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