期刊
BIOMEDICAL AND ENVIRONMENTAL SCIENCES
卷 23, 期 1, 页码 21-31出版社
CHINESE CENTER DISEASE CONTROL & PREVENTION
DOI: 10.1016/S0895-3988(10)60027-X
关键词
Waist circumference; Cardiovascular disease risk factor; China
资金
- International Life Science Institute Focal Point in China
- Ministry of Health and Ministry of Science and Technology in China [2001DEA30035, 2003DIA6N08]
- Department of Paediatrics
- Chinese University of Hong Kong and Hong Kong Paediatric Society [H030930030130]
- Beijing Municipal Science and Technology Commission [Y043204, NSFC30500419]
- Program for New Century Excellent Talents in University of China
- Chongqing Health Bureau [07-2-156]
- State Sport General Administration [06134]
- Eleventh Five-Year Plan of Beijing's Haidtan District
- European Nutricia Fund
Objectives To explore the optimal threshold values of waist circumference (WC) for detecting cardiovascular (CV) risk factors among Chinese children and adolescents Methods Association of WC with CV risk factors was studied among 65 898 children aged 7-18 years whose data were pooled from nine previous studies in China CV risk factors in this study included hypertension (blood pressure above 95 percentile levels), dyslipidemia (with one or more of the following three indexes TG >= 17 mmol/L, TC >= 5 18 mmol/L, and HDL-C <= 1 04 mmol/L) and elevated glucose level (fasting plasma glucose >= 5 6 mmol/L) Receive-operating characteristic analysis (ROC) and logistic regression were employed to derive optimal age- and sex-specific waist circumference references for predicting CV risk factors Results A slight increasing trend of CV risk factors was observed starting from the 75th percentile of waist circumference in the study population. while a remarkable increasing trend occurred from the 90th percentile The optimal waist circumference thresholds for predicting high blood pressures were at the 75th percentile for both boys and girls. which was at the 90th percentiles for detecting at least two of the above three CV risk factors In comparison with children with waist circumference below the 75th percentile, the odds ratio of two CV risk factors doubled among children with waist circumference between the 75th and the 90th percentile, and increased by 6 times among children with wait circumference above the 90th percentile The trend of high blood pressure increasing with waist circumference remained significant after having been stratified by BMI category Conclusion The 75th and the 90th percentiles of WC are the optimal cut-off points for predicting an increased and a substantially increased risk of CV factors in Chinese children and adolescents, respectively
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