期刊
BIOMEDICAL AND ENVIRONMENTAL SCIENCES
卷 21, 期 6, 页码 467-473出版社
CHINESE CENTER DISEASE CONTROL & PREVENTION
DOI: 10.1016/S0895-3988(09)60004-0
关键词
Iron toxicosis; Transferable; Phenotype; Behavior; C elegans
资金
- Southeast University Foundation for Excellent Young Scholars [4023001013]
Objective Previous work has showed that excess iron accumulation is harmful to reproduction and even promotes death; however, whether the multiple biological toxicity of iron (Fe) exposure could be transferred to progeny remains unknown. The present study used Caenorhabditis elegans to analyze the multiple toxicities of iron exposure and their possible transferable properties. Methods Three concentrations of iron sulfate solution (2.5 mu mol/L, 75 mu mol/L, and 200 mu mol/L) were used. The endpoints of lifespan, body size, generation time, brood size, head thrash and body bend frequencies, and chemotaxis plasticity were selected to investigate Fe toxicity and its effect on progeny in Caenorhabditis elegans. Results The Fe toxicity could cause multiple biological defects in a dose-dependent manner by affecting different endpoints in nematodes. Most of the multiple biological defects and behavior toxicities could be transferred from Fe-exposed Caenorhabditis elegans to their progeny. Compared to the parents, no recovery phenotypes were observed for some of the defects in the progeny, such as body bend frequency and life span. We further summarized the defects caused by Fe exposure into 2 groups according to their transferable properties. Conclusion Our results suggest that Fe exposure could cause multiple biological defects, and most of these severe defects could be transferred from Fe exposed nematodes to their progeny.
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