期刊
EMBO JOURNAL
卷 19, 期 6, 页码 1290-1300出版社
OXFORD UNIV PRESS
DOI: 10.1093/emboj/19.6.1290
关键词
brain-derived neurotrophic factor (BDNF); hypothalamus; neurotrophins; obesity; TrkB
资金
- NCRR NIH HHS [P41-RR02584, P41 RR002584] Funding Source: Medline
- NINDS NIH HHS [R37 NS033199, R01 NS33199-05] Funding Source: Medline
Brain-derived neurotrophic factor (BDNF) was studied initially for its role in sensory neuron development, Ablation of this gene in mice leads to death shortly after birth, and abnormalities have been found in both the peripheral and central nervous systems. BDNF and its tyrosine kinase receptor, TrkB, are expressed in hypothalamic nuclei associated with satiety and locomotor activity. In heterozygous mice, BDNF gene expression is reduced and we find that all heterozygous mice exhibit abnormalities in eating behavior or locomotor activity, We also observe this phenotype in independently derived inbred and hybrid BDNF mutant strains. Infusion with BDNF or NT4/5 can transiently reverse the eating behavior and obesity. Thus, we identify a novel non-neurotrophic function for neurotrophins and indicate a role in behavior that is remarkably sensitive to alterations in BDNF activity.
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