期刊
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
卷 11, 期 3-4, 页码 533-542出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s10237-011-0331-1
关键词
Collagen fiber orientation; Parameter estimation; Coronary arteries; Netting analysis
资金
- Dutch Technology Foundation STW [SmartSiP 10046]
- Philips Research
- St. Jude Medical.
A patient-specific mechanical description of the coronary arterial wall is indispensable for individualized diagnosis and treatment of coronary artery disease. A way to determine the artery's mechanical properties is to fit the parameters of a constitutive model to patient-specific experimental data. Clinical data, however, essentially lack information about the stress-free geometry of an artery, which is necessary for constitutive modeling. In previous research, it has been shown that a way to circumvent this problem is to impose extra modeling constraints on the parameter estimation procedure. In this study, we propose a new modeling constraint concerning the in-situ fiber orientation (beta (phys)). beta (phys), which is a major contributor to the arterial stress-strain behavior, was determined for porcine and human coronary arteries using a mixed numerical-experimental method. The in-situ situation was mimicked using in-vitro experiments at a physiological axial pre-stretch, in which pressure-radius and pressure-axial force were measured. A single-layered, hyperelastic, thick-walled, two-fiber material model was accurately fitted to the experimental data, enabling the computation of stress, strain, and fiber orientation. beta (phys) was found to be almost equal for all vessels measured (36.4 +/- 0.3)A degrees, which theoretically can be explained using netting analysis. In further research, this finding can be used as an extra modeling constraint in parameter estimation from clinical data.
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