期刊
CELL
卷 100, 期 6, 页码 655-669出版社
CELL PRESS
DOI: 10.1016/S0092-8674(00)80702-3
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资金
- NIAID NIH HHS [AI/AG 37833, AI 36535, AI 39646] Funding Source: Medline
Naive T helper cells differentiate into two subsets, Th1 and Th2, each with distinct functions and cytokine profiles. Here, we report the isolation of T-bet, a Th1-specific T box transcription factor that controls the expression of the hallmark Th1 cytokine, IFN gamma. T-bet expression correlates with IFN gamma expression in Th1 and NK cells. Ectopic expression of T-bet both transactivates the IFN gamma gene and induces endogenous IFN gamma production. Remarkably, retroviral gene transduction of T-bet into polarized Th2 and Tc2 primary T cells redirects them into Th1 and Tc1 cells, respectively, as evidenced by the simultaneous induction of IFN gamma and repression of IL-4 and IL-5. Thus, T-bet initiates Th1 lineage development from naive Thp cells both by activating Th1 genetic programs and by repressing the opposing Th2 programs.
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