期刊
BIOMATERIALS
卷 187, 期 -, 页码 47-54出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2018.09.019
关键词
Aggregation-induced emission; Gram-positive bacteria; Specificity; Discrimination; Visualization
资金
- National Natural Science Foundation of China [21788102, 51673118, 51603127]
- National Program for Support of Top-Notch Young Professionals (China)
- Natural Science Fund of Guangdong Province, China [2016A030312002, 2014A030313659]
- Science & Technology Program of Guangzhou, China [201804010218]
- Science and Technology Plan of Shenzhen, China [JCYJ20160428150429072, JCYJ20160229205601482]
- Innovation and Technology Commission of Hong Kong, China [ITC-CNERC14S01]
- Fundamental Research Funds for the Central Universities, China [2015ZY013, 2017JQ013, 2017B0036]
- Chinese Postdoctoral Science Foundation, China [2017M612647]
The infections caused by gram-positive bacteria (G(+)) is a major threat to public health due to their high morbidity and mortality, and the identification of G(+) with high sensitivity and selectivity is urgently desirable. In this paper, a probe with aggregation-induced emission (AIE) characteristic is developed and used to discriminate G(+) from other bacteria and fungus with excellent selectivity. Thanks for its ATE feature, this probe shows intense fluorescence when interacted with G(+), and the signal can last for 24 h after incubating with S. aureus, which is benefit for long term tracing of translocation process with high contrast. Moreover, this probe can be used to visualize the infection processes of G(+) towards mammalian cells, which provides valuable information for understanding the therapeutic mechanism.
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