期刊
BIOMATERIALS
卷 183, 期 -, 页码 234-242出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2018.08.036
关键词
in situ method; Protein-polymer nanoparticle; Virus-mimicking; Antigen-specific immune activation; Influenza vaccine
资金
- Mid-career Researcher Program through the National Research Foundation - Korean government (MSIP) [2013R1A2A2A01068818]
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute - Ministry of Health & Welfare, Republic of Korea [HI 16C0973]
- National Science and Technology Major Project, Ministry of Science and Technology of China [2017ZX09304027]
The generation of virus-mimetic nanoparticles has received much attention in developing a new vaccine for overcoming the limitations of current vaccines. Thus, a method, encompassing most viral features for their size, hydrophobic domain and antigen display, would represent a meaningful direction for the vaccine development. In the present study, a polymer-templated protein nanoball with direction oriented hemagglutininl on its surface (H1-NB) was prepared as a new influenza vaccine, exhibiting most of the viral features. Moreover, the concentrations of antigen on the particle surface were controlled, and its effect on immunogenicity was estimated by in vivo studies. Finally, H1-NB efficiently promoted H1-specific immune activation and cross-protective activities, which consequently prevented H1N1 infections in mice.
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