期刊
BIOMATERIALS
卷 181, 期 -, 页码 92-102出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2018.07.042
关键词
Semiconducting polymer nanoparticles; High photothermal conversion efficiency; Photoacoustic imaging; Photothermal therapy; Cancer theranostics
资金
- Applied Research Grant (ARG) from Grants Committee of City University of Hong Kong, Hong Kong, PR China
Understanding the relationship between polymer chemical structure and its performance of photoacoustic imaging (PAI) and photothermal therapy (PTT) is important for developing ideal PAI/PTT agents. In this report, four semiconducting polymer nanoparticles (SPNs) with different donor-acceptor architectures are self-assembled for highly effective PAI-guided PIT. In particular, SPN1 with the longest pi-conjugation length and the highest mass extinction coefficient which are beneficial for intramolecular charge transfer as well as light harvesting, exhibits the highest photothermal conversion efficiency up to 52.6%. Moreover, the as-prepared SPN1 possess good water-dispersibility, robust size-stability and excellent photothermal properties. Furthermore, the SPN1 not only exhibits a remarkable cancer cell-killing ability but also shows a prominent tumor inhibition capacity. Finally, the as-prepared water-dispersible SPN1 displays good biocompatibility and biosafety, making it a promising candidate for future biomedical applications. Considering the plenty of near-infrared absorbing semiconducting polymer available, our work provides fundamental insights for rational design and preparation of highly efficient SPN-based PAI/PTT agents for cancer theranostics. (C) 2018 Elsevier Ltd. All rights reserved.
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