期刊
BIOMATERIALS
卷 196, 期 -, 页码 2-17出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2018.07.029
关键词
Vascular disease; 3D printing; Organ-on-a-chip; Tissue modeling
资金
- Texas A&M University Graduate Diversity fellowship
- National Science Foundation [CBET 1705852]
- National Institutes of Health [DP2 EB026265, R03 EB023454]
- Texas A&M Engineering Experiment Station (TEES)
- Texas AM University
Most biomedical and pharmaceutical research of the human vascular system aims to unravel the complex mechanisms that drive disease progression from molecular to organ levels. The knowledge gained can then be used to innovate diagnostic and treatment strategies which can ultimately be determined precisely for patients. Despite major advancements, current modeling strategies are often limited at identifying, quantifying, and dissecting specific cellular and molecular targets that regulate human vascular diseases. Therefore, development of multiscale modeling approaches are needed that can advance our knowledge and facilitate the design of next-generation therapeutic approaches in vascular diseases. This article critically reviews animal models, static in vitro systems, and dynamic in vitro culture systems currently used to model vascular diseases. A leading emphasis on the potential of emerging approaches, specifically organ-on-a-chip and three-dimensional (3D) printing, to recapitulate the innate human vascular physiology and anatomy is described. The applications of these approaches and future outlook in designing and screening novel therapeutics are also presented. (C) 2018 Elsevier Ltd. All rights reserved.
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