期刊
BIOMATERIALS
卷 35, 期 7, 页码 2272-2282出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2013.11.068
关键词
Multidrug resistance; Multifunctional nanoparticle; Chemo-photothermal treatment; Near infrared resonance; Photothermally controlled drug delivery
资金
- MEST through the National Research Foundation (NRF) of Korea [NRF-2012R1A4A1029061, NRF-2011-0017611, NRF-2013R1A1A304009309]
- Brain Korea 21 Plus Project for Medical Sciences
- Brain Korea 21 Plus Project for Physics
- MHW through the Korean Health Technology RD Project [A110905]
- Korea Health Promotion Institute [A110905] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
To investigate the possibility of treating multidrug-resistant tumors with targeted chemo-photothermal treatment, we conducted in vitro and in vivo studies using a doxorubicin (DOX)-resistant DLD-1 cell line (DLD-1/DOX) and nude mice with human xenograft tumors, respectively. The chemo-photothermal treatment consisted of DOX-loaded-poly(lactic-co-glycolic acid)-Au half-shell nanoparticles with targeting moieties of anti-death receptor-4 monoclonal antibody conjugated to the Au surface. The cells or xenografted tumors treated with nanoparticles were exposed to near infrared light for 10 min, which caused an increase in temperature to 45 degrees C. Chemo-photothermal treatment resulted in a large reduction in the rate of tumor xenograft growth on DLD-1/DOX tumor-bearing mice with a much smaller dose of DOX than conventional DOX chemotherapy. These results demonstrate that targeted chemophotothermal treatment can provide high therapeutic efficacy and low toxicity in the treatment of multidrug-resistant tumors. (C) 2013 Elsevier Ltd. All rights reserved.
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