期刊
BIOMATERIALS
卷 35, 期 9, 页码 2692-2712出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2013.12.016
关键词
Neural tissue engineering; Brain repair; BDNF-mimetic; Neuroblast migration; PCL scaffold; Subventricular zone
资金
- Australian Research Council [DP0985433]
- ARC Future Fellowship scheme
- Monash-CSIRO collaboration fund
- Australian Research Council [DP0985433] Funding Source: Australian Research Council
Brain tissue engineering has the potential to harness existing elements of neurogenesis within the adult brain to overcome a microenvironment that is otherwise inhibitory to regeneration, especially following severe tissue damage. This study investigates the ability of electrospun poly epsilon-caprolactone (PCL) to redirect the migratory pathway of endogenous neuroblasts from the disrupted subventricular zone (SVZ). A small molecule non-peptide ligand (BDNF-mimetic) that mimicked the trophic properties of brain-derived neurotrophic factor (BDNF) was incorporated into electrospun PCL scaffolds to improve neuroblast survival and promote neuroblast migration towards the implant. PCL scaffolds were able to support neuroblast infiltration and migration along the implant tract. In the presence of the BDNF-mimetic, neuroblasts were able to migrate towards the implant via the parenchyma, and their persistence within the implants was prolonged. In addition, the BDNF-mimetic improved implant integration and increased local neuronal plasticity by increasing neurite sprouting at the tissue-implant interface. SMI32+ neurites were observed inside scaffolds at 21 days but not 8 days post implantation, indicating that at least some of the infiltrated neuroblasts had differentiated into neurons. (C) 2013 Elsevier Ltd. All rights reserved.
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