期刊
BIOMATERIALS
卷 35, 期 6, 页码 1954-1966出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2013.11.066
关键词
Gold nanorods; Rose bengal; Oral cancer; Photodynamic therapy; Photothermal therapy
资金
- Wuhan Science and Technology project [20026002084]
- Natural Science Foundation of China (NSFC) [51372175]
- Hong Kong Research Grants Council (RGC) General Research Funds (GRF) [112510]
- City University of Hong Kong Applied Research Grants (ARG) [9667066, 9667069]
Gold nanorods (GNRs) conjugated with rose bengal (RB) molecules exhibit efficient singlet oxygen generation when illuminated by 532 nm green light and high photothermal efficiency under 810 nm near-infrared (NIR) irradiation. In vitro experiments show that reactive oxygen species generated by green light and hyperthermia produced by NIR light constitute two different mechanisms for cancer cell death. The RB-GNRs also exhibit improved photodynamic efficacy by enhancing the uptake of RB by cancer cells. In vivo experiments are conducted on hamster cheek pouches to resemble the human oral cancer conditions more accurately to assess the therapeutic effectiveness. Compared to the single photodynamic therapy (PDT) or photothermal therapy (PTT), the RB-GNRs with combined PDT-PIT capabilities provide better therapeutic effects against oral cancer and have large potential in cancer treatment. (C) 2013 Elsevier Ltd. All rights reserved.
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