期刊
ORGANIC LETTERS
卷 2, 期 6, 页码 775-777出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol9913901
关键词
-
资金
- NCI NIH HHS [CA63572] Funding Source: Medline
Asymmetric aldol additions using chlorotitanium enolates of thiazolidinethione propionates proceed with high diastereoselectivity for the Evans or non-Evans syn product depending on the nature and amount of the base used. With (-)-sparteine as the base, selectivities of 97:3 to >99:1 were obtained for the Evans syn products with 2 equivalents of base and for the non-Evans syn when 1 equiv of base was employed. The thiazolidinethione auxiliaries are easily removed, and the aldol adducts can be readily transformed to various functional groups. Even direct reduction to the aldehyde with diisobutylaluminum hydride is possible.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据