期刊
BIOMATERIALS
卷 35, 期 10, 页码 3164-3171出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2013.12.098
关键词
Magnetic field; Cell proliferation; Reactive oxygen species; Leukemia; Apoptosis; Modeling
资金
- DFG [SPP1313]
- Academy of Sciences of the Czech Republic [M100101219]
The influence of spatially modulated high gradient magnetic fields on cellular functions of human THP-1 leukemia cells is studied. We demonstrate that arrays of high-gradient micrometer-sized magnets induce i) cell swelling, ii) prolonged increased ROS production, and iii) inhibit cell proliferation, and iv) elicit apoptosis of THP-1 monocytic leukemia cells in the absence of chemical or biological agents. Mathematical modeling indicates that mechanical stress exerted on the cells by high magnetic gradient forces is responsible for triggering cell swelling and formation of reactive oxygen species followed by apoptosis. We discuss physical aspects of controlling cell functions by focused magnetic gradient forces, i.e. by a noninvasive and nondestructive physical approach. (C) 2014 Elsevier Ltd. All rights reserved.
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