期刊
SCIENCE
卷 287, 期 5461, 页码 2260-2262出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.287.5461.2260
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资金
- NIDDK NIH HHS [KO8 DK02578] Funding Source: Medline
- NIGMS NIH HHS [GM55772] Funding Source: Medline
Correct positioning of the mitotic spindle is critical for cell division and development. Spindle positioning involves a search-and-capture mechanism whereby dynamic microtubules find and then interact with specific sites on the submembrane cortex. Genetic, biochemical, and imaging experiments suggest a mechanism for cortical-microtubule capture. Bim1p, Located at microtubule distal ends, bound Kar9p, a protein associated with the daughter cell cortex. Bim1p is the yeast ortholog of human EB1, a binding partner for the adenomatous polyposis coli tumor suppressor. EB1 family proteins may have a general role in linking the microtubule cytoskeleton to cortical polarity determinants.
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