期刊
BIOMATERIALS
卷 35, 期 23, 页码 6037-6046出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2014.04.019
关键词
Indocyanine green; Lipid-polymer nanoparticle; Endocytosis; Biodistribution; Photothermal therapy
资金
- National Natural Science Foundation of China [81071249, 81171446, 21375141]
- Natural Science Foundation of Guangdong Province of China [9478922035-X003399]
- China Postdoctoral Science Foundation [20090450587]
- Guangdong Innovation Reasearch Team of Low-cost Healthcare. Science and Technology Project of Shenzhen [CXB201005250029A, JC201005270326A, JC201104220242A, JC201005260247A]
A key challenge to strengthen anti-tumor efficacy is to improve drug accumulation in tumors through size control. To explore the biodistribution and tumor accumulation of nanoparticles, we developed indocyanine green (ICG) loaded poly (lactic-co-glycolic acid) (PLGA) -lecithin-polyethylene glycol (PEG) core-shell nanoparticles (INPs) with 39 nm, 68 nm and 116 nm via single-step nanoprecipitation. These INPs exhibited good monodispersity, excellent fluorescence and size stability, and enhanced temperature response after laser irradiation. Through cell uptake and photothermal efficiency in vitro, we demonstrated that 39 nm INPs were more easily be absorbed by pancreatic carcinoma tumor cells (BxPC-3) and showed better photothermal damage than that of 68 nm and 116 nm size of INPs. Simultaneously, the fluorescence of INPs offered a real-time imaging monitor for subcellular locating and in vivo metabolic distribution. Near-infrared imaging in vivo and photothermal therapy illustrated that 68 nm INPs showed the strongest efficiency to suppress tumor growth due to abundant accumulation in BxPC-3 xenograft tumor model. The findings revealed that a nontoxic, size-dependent, theranostic INPs model was built for in vivo cancer imaging and photothermal therapy without adverse effect. (C) 2014 Elsevier Ltd. All rights reserved.
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