期刊
BIOMATERIALS
卷 35, 期 37, 页码 9868-9876出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2014.08.038
关键词
Gold nanocluster; Cu-64 doping; Cerenkov effect; Positron emission tomography; Optical imaging
资金
- National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
- National Key Basic Research Program (973 Project) [2010CB933901, 2013CB733802, 2014CB744503]
- National Natural Science Foundation of China [81272987, 81090270, 81090273, 81401465, 81370585]
Self-illuminating fluorescence imaging without autofluorescence background interference has recently aroused more research interests in molecular imaging. Currently, only a few self-illuminating probes were developed, based mainly on toxic quantum dots such as CdSe, CdTe. Herein, we report a novel design of nontoxic self-illuminating gold nanocluster (Cu-64-doped AuNCs) for dual-modality positron emission tomography (PET) and near-infrared (NIR) fluorescence imaging based on Cerenkov resonance energy transfer (CRET). PET radionuclide Cu-64 was introduced by a chelator-free doping method, which played dual roles as the energy donor and the PET imaging source. Meanwhile, AuNCs acted as the energy acceptor for NIR fluorescence imaging. Cu-64-doped AuNCs exhibited efficient CRET-NIR and PET imaging both in vitro and in vivo. In a U87MG glioblastoma xenograft model, Cu-64-doped AuNCs showed high tumor uptake (14.9 %ID/g at 18 h) and produced satisfactory tumor self-illuminating NIR images in the absence of external excitation. This self-illuminating nanocluster with non-toxicity and good biocompatibility can be employed as a novel imaging contrast agent for biomedical applications, especially for molecular imaging. Published by Elsevier Ltd.
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