期刊
BIOMATERIALS
卷 35, 期 14, 页码 4249-4254出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2014.01.080
关键词
Bacteria; Adhesion; Nanostructure; Nanocrystalline; Staphylococcus aureus; Nano-pillar
资金
- Natural Sciences and Engineering Council of Canada, NSERC
- National Science Foundation via the CAREER award [CBET-0955291]
- Department of Chemical Engineering
- Nanomechanics Research Institute at the University of Waterloo
- Directorate For Engineering [0955291] Funding Source: National Science Foundation
- Div Of Chem, Bioeng, Env, & Transp Sys [0955291] Funding Source: National Science Foundation
A broad range of human diseases are associated with bacterial infections, often initiated by specific adhesion of a bacterium to the target environment. Despite the significant role of bacterial adhesion in human infectious diseases, details and mechanisms of bacterial adhesion have remained elusive. Herein, we study the physical interactions between Staphylococcus aureus, a type of micro-organism relevant to infections associated with medical implants, and nanocrystalline (nc) nickel nanostructures with various columnar features, including solid core, hollow, x-shaped and c-shaped pillars. Scanning electron microscopy results show the tendency of these bacterial cells to attach to the nickel nanostructures. Moreover, unique single bacterium attachment characteristics were observed on nickel nanostructures with dimensions comparable to the size of a single bacterium. (C) 2014 Elsevier Ltd. All rights reserved.
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