期刊
BIOMATERIALS
卷 35, 期 25, 页码 6918-6929出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2014.05.003
关键词
Self-healing materials; Reversible bonds; Organic-inorganic nanocomposites; Hydrogels; Bone regeneration
资金
- SmartMix Program (TeRM project) of the Netherlands Ministry of Economic Affairs and Ministry of Education
- Culture and Science, Netherlands
- European Community [238551]
Non-covalent interactions are often regarded as insufficient to construct macroscopic materials of substantial integrity and cohesion. However, the low binding energy of such reversible interactions can be compensated by increasing their number to work in concert to create strong materials. Here we present the successful development of an injectable, cohesive nanocomposite hydrogel based on reversible bonds between calcium phosphate nanoparticles and bisphosphonate-functionalized hyaluronic acid. These nanocomposites display a capacity for self-healing as well as adhesiveness to mineral surfaces such as enamel and hydroxyapatite. Most importantly, these non-covalently cross-linked composites are surprisingly robust yet biodegradable upon extensive in vitro and in vivo testing and show bone interactive capacity evidenced by bone ingrowth into material remnants. The herein presented method provides a new methodology for constructing nanoscale composites for biomedical applications, which owe their integrity to reversible bonds. (C) 2014 Elsevier Ltd. All rights reserved.
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