期刊
BIOMATERIALS
卷 35, 期 36, 页码 9689-9697出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2014.08.021
关键词
Upconversion nanophosphors; Long-lasting real-time tracking; Synergistic in vivo fluorescence and X-ray bioimaging; Biodistribution
资金
- National Natural Science Foundation of China [51102202, 31370736]
- Specialized Research Fund for the Doctoral Program of Higher Education of China [20114301120006]
- Hunan Provincial Natural Science Foundation of China [12JJ4056]
- Hunan Provincial Education Department [13B062]
Simultaneous in vivo luminescence and X-ray bioimaging in a tissue or animal integrates the advantages of each single-modal imaging technology, and will find widespread application in biological and clinical fields. However, synergistic dual-modal bioimaging that utilizes a new generation of upconversion nanoprobes is still limited. In addition, investigations concentrated on in vivo biodistribution of these nanoprobes may contribute to diagnosis and treatment, but long-term in vivo tracking based on these nanoprobes is rarely reported. In this work, water-soluble NaLuF4: Yb/Er nanophosphors were prepared through modified one-pot simultaneous synthesis and surface modification method. Owing to the outstanding upconverting emissions and large X-ray absorption coefficient/K-edge value of Lu and doped Yb ions, the obtained nanoprobes were successfully used as luminescent nanoprobes and X-ray contrast agents for in vivo synergistic upconversion luminescence and X-ray bioimaging. The in vivo biodistribution of these nanoprobes were observed, and the results based on long-term tracking reveal that the as-prepared nanoprobes first aggregated in the lung of the mouse, transferred to the liver, and finally moved to the spleen. (C) 2014 Elsevier Ltd. All rights reserved.
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