期刊
BIOMATERIALS
卷 35, 期 22, 页码 5814-5821出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2014.04.005
关键词
Prussian blue; Au nanoparticles; X-ray computed tomography; Photoacoustic imaging; Photothermal therapy
资金
- National Natural Science Foundation for Distinguished Young Scholars [81225011]
- State Key Program of National Natural Science of China [81230036]
- National Natural Science Foundation of China [81371580, 21273014]
- Natural Science Foundation of Heilongjiang Province for Distinguished Young Scholars [JC201112]
The combination of CT imaging and photoacoustic (PA) imaging represents not only high resolution and ease of forming 3D visual image for locating tissues of interest, but also good soft tissue contrast and excellent high sensitivity, which is very beneficial to the precise guidance for photothermal therapy (PIT). The near infrared (NIR) absorbing Au nanostructures take advantages to operate as a CT contrast agent due to high absorption coefficient of X-ray and outstanding biocompatibility, but show obvious deficiency for PA imaging and PTT because of low photostability. Attacking this problem head on, the Au nanoparticles (NPs) were coated with Prussian blue (PB) which is a typical FDA-approved drug in clinic for safe and effective treatment of radioactive exposure. The obtained core/shell NPs of Au@PB NPs of 17.8 +/- 2.3 nm were found to be an excellent photoabsorbing agent for both PIT and PA imaging due to high photostability and high molar extinction coefficient in NIR region. Their gold core of 9.1 +/- 0.64 nm ensured a remarkable contrast enhancement for CT imaging. Through a one-time treatment of NIR laser irradiation after intravenous injection of Au@PB NPs, 100 mm(3) sized tumors in nude mice could be completely ablated without recurrence. Such versatile nanoparticles integrating effective cancer diagnosis with noninvasive therapy might bring opportunities to future cancer therapy. (C) 2014 Elsevier Ltd. All rights reserved.
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