期刊
BIOMATERIALS
卷 35, 期 1, 页码 387-392出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2013.09.110
关键词
Cysteine; Modification; Upconversion nanoparticles; Biocompatibility; Bioimaging
资金
- National Natural Science Foundation of China [21001072, 21231004, 21201117]
- Innovation Program of Shanghai Municipal Education Commission [13ZZ073]
- Shanghai Sci. Tech. Comm. [13NM1401100, 13NM1401101]
- Key Subject of Shanghai Municipal Education Commission [150102]
- US NSF
- BES Division of the US DOE
Cysteine, as a small organic molecule and amino acid, is a basic building block for proteins and has special physiological functions in vivo. Cysteine has strong affinity for cells, which can be taken advantage for various applications. A new and facile surface modification method has been developed for rare-earth doped upconversion nanoparticles (UCNs) using cysteine. Compared with unmodified samples, the water-solubility and biocompatibility of the cysteine modified NaYF4:Yb,Er and NaYF4:Yb,Tm UCNs (termed as UCN-Er-Cys and UCN-Tm-Cys, respectively) have been significantly improved, while their particle size and emission properties did not change substantially. Due to the low cytotoxicity as revealed by methyl thiazolyl tetrazolium assay, the cysteine modified UCNs were successfully applied to imaging of Hela cells in vitro and nude mouse in vivo. Most significant is that the method offers the advantages of ease of synthesis and handling as well as potentially low cost for biomedical emerging applications. (C) 2013 Elsevier Ltd. All rights reserved.
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