期刊
TETRAHEDRON LETTERS
卷 41, 期 13, 页码 2185-2188出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(00)00131-3
关键词
benzofurans; bioluminescence; benzothiophenes; indoles
dl-Cypridina luciferin and its analogues were synthesized from 2-aminopyrazine by an eight-step method that included two regio-selective Pd-mediated cross couplings, and their chemi- and bioluminescent activities were compared. Analogues having a 3-benzofuranyl or a 3-benzothienyl group in the place of a 3-indolyl group showed luciferase affinities similar to Cypridina luciferase but with a lower luminescent efficiency, suggesting that the NH group is unimportant for molecular recognition whereas the indolyl group is crucial for efficient luminescence. (C) 2000 Elsevier Science Ltd. All rights reserved.
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