期刊
BIOMATERIALS
卷 34, 期 27, 页码 6377-6387出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2013.05.005
关键词
Curcumin; Micelles; Thermosenstitive hydrogel; Dermal wound healing; Poly(ethylene glycol); Poly(epsilon-caprolactone)
资金
- National Natural Science Foundation [NSFC31271021, NSFC31222023, NSFC81201724]
- National Science and Technology Major Project [2011ZX09102-001-10]
- Sichuan Key Technology RD Program [2011SZ0219, 2013SZ0018]
- Specialized Research Fund for the Doctoral Program of Higher Education [20120181120044]
- Chinese Key Basic Research Program [2010CB529906]
A biodegradable in situ gel-forming controlled drug delivery system composed of curcumin loaded micelles and thermosensitive hydrogel was prepared and applied for cutaneous wound repair. Curcumin is believed to be a potent antioxidant and anti-inflammatory agent. Due to its high hydrophobicity, curcumin was encapsulated in polymeric micelles (Cur-M) with high drug loading and encapsulation efficiency. Cur-M loaded thermosensitive hydrogel (Cur-M-H) was prepared and applied as wound dressing to enhance the cutaneous wound healing. Cur-M-H was a free-flowing sol at ambient temperature and instantly converted into a non-flowing gel at body temperature. In vitro studies suggested that Cur-M-H exhibited well tissue adhesiveness and could release curcumin in an extended period. Furthermore, linear incision and full-thickness excision wound models were employed to evaluate the in vivo wound healing activity of Cur-M-H. In incision model, Cur-M-H-treated group showed higher tensile strength and thicker epidermis. In excision model, Cur-M-H group exhibited enhancement of wound closure. Besides, in both models, Cur-M-H-treated groups showed higher collagen content, better granulation, higher wound maturity, dramatic decrease in superoxide dismutase, and slight increase in catalase. Histopathologic examination also implied that Cur-M-H could enhance cutaneous wound repair. In conclusion, biodegradable Cur-M-H composite might have great application for wound healing. (C) 2013 Elsevier Ltd. All rights reserved.
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