期刊
BIOMATERIALS
卷 34, 期 4, 页码 1402-1412出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2012.10.071
关键词
Electrospinning; Poly(lactic-co-glycolic acid); Nano-hydroxyapatite; Amoxicillin; Sustained release; Antibacterial activity
资金
- High-Tech Research and Development Program of China, [2012AA030309]
- Program for New Century Excellent Talents in University, State Education Ministry
- Fund of the Science and Technology Commission of Shanghai Municipality [11nm0506400]
- Fundamental Research Funds for the Central Universities
- National Natural Science Foundation of China [50925312]
- 111 Project [B07024]
We report a facile approach to fabricating electrospun drug-loaded organic/inorganic hybrid nanofibrous system for antibacterial applications. In this study, nano-hydroxyapatite (n-HA) particles loaded with a model drug, amoxicillin (AMX) were dispersed into poly(lactic-co-glycolic acid) (PLGA) solution to form electrospun hybrid nanofibers. The loading of AMX onto n-HA surfaces (AMX/n-HA) and the formation of AMX/n-HA/PLGA composite nanofibers were characterized using different techniques. We show that AMX can be successfully adsorbed onto the n-HA surface and the formed AMX/n-HA/PLGA composite nanofibers have a uniform and smooth morphology with improved mechanical durability. Cell viability assay and cell morphology observation reveal that the formed AMX/n-HA/PLGA composite nanofibers are cytocompatible. Importantly, the loaded AMX within the n-HA/PLGA hybrid nanofibers shows a sustained release profile and a non-compromised activity to inhibit the growth of a model bacterium, Staphylococcus aureus. With the significantly reduced burst-release profile, good cytocompatibility, improved mechanical durability, as well as the remained antibacterial activity, the developed AMX/n-HA/PLGA composite nanofibers should find various potential applications in the fields of tissue engineering and pharmaceutical science. (C) 2012 Elsevier Ltd. All rights reserved.
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