期刊
FEBS LETTERS
卷 470, 期 3, 页码 325-330出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(00)01337-5
关键词
hepatocyte growth factor; oval cell; Solt-Farber model; liver regeneration
To clarify the effect of hepatocyte growth factor (HGF) on proliferation of hepatic oval cells, rye transferred HGF gene into liver of the Solt-Farber rat model. Male Fisher 344 rats mere infected with a recombinant adenovirus carrying the cDNA for HGF (pAxCAHGF) from tail vein. HGF mRNA showed its peak at 4 days, and diminished thereafter. The total and proliferating cell nuclear antigen-positive hepatic oval cells were significantly elevated in HGF-transferred rats, in which stem cell factor and c-kit mRNA increased at each time point. Our results suggest that in vivo transfer of the HGF gene into liver accelerates proliferation of hepatic oval cells in the Solt-Farber model in rats. (C) 2000 Federation of European Biochemical Societies.
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