期刊
SCIENCE
卷 287, 期 5462, 页码 2494-2497出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.287.5462.2494
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资金
- NIGMS NIH HHS [GM58800] Funding Source: Medline
In Caenorhabditis elegans, the introduction of double-stranded RNA Triggers sequence-specific generic interference (RNAi) that is transmitted to offspring. The inheritance properties associated with this phenomenon were examined. Transmission of the interference effect occurred through a dominant extragenic agent. The wild-type activities of the RNAi pathway genes rde-1 and rde-4 were required for the formation of this interfering agent but were not needed for interference thereafter. In contrast, the rde-2 and mut-7 genes were required downstream for interference. These findings provide evidence for germ line transmission of an extragenic sequence-specific silencing factor and implicate rde-1 and rde-4 in the formation of the inherited agent.
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