期刊
BIOMATERIALS
卷 34, 期 9, 页码 2194-2201出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2012.11.061
关键词
Cerium oxide nanoparticles; Vascular endothelial cells; Keratinocytes; Fibroblasts; Wound healing; Oxidative stress
资金
- National Institute on Aging Intramural Research Program of the NIH
- National Science Foundation (NIRT: CBET)
Rapid and effective wound healing requires a coordinated cellular response involving fibroblasts, keratinocytes and vascular endothelial cells (VECs). Impaired wound healing can result in multiple adverse health outcomes and, although antibiotics can forestall infection, treatments that accelerate wound healing are lacking. We now report that topical application of water soluble cerium oxide nanoparticles (Nanoceria) accelerates the healing of full-thickness dermal wounds in mice by a mechanism that involves enhancement of the proliferation and migration of fibroblasts, keratinocytes and VECs. The Nanoceria penetrated into the wound tissue and reduced oxidative damage to cellular membranes and proteins, suggesting a therapeutic potential for topical treatment of wounds with antioxidant nanoparticles. Published by Elsevier Ltd.
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